Although there are many treatments for TMD, therapy specific to degenerative pathology of the TMJ disc itself is limited in scope and therapeutic effect. Consider Wharton’s jelly for Connective Tissue Supplementation to repair or replace the damaged tissue with new healthy connective tissue.


Contact Us
man holding jaw with pain

CryoText (Wharton’s jelly allograft) for TMJ Defects

Wharton’s jelly (WJ) allografts consist of human umbilical cord tissue that has been disassociated, suspended in saline, and cryopreserved. Their main function is to provide cushioning and structural support and to replace missing or damaged tissue in the patient, applied directly to the defect, or injured area, in soft tissues. They are applied via syringe and are typically used in ligament, muscle, or cartilage tears.

AmnioText (Dual-layer amniotic membrane graft) for Surgery on Gum and BonE

Guided Tissue Regeneration (GTR)

The gum is opened with a procedure known as a flap. The area under the gum is cleaned out to remove all bacterial deposits. Then a membrane (with or without a bone graft material) is placed over the damaged bone separating the tissues to prevent the soft faster growing gum tissue from growing into the bone space. Once in place between bone and gum, the membrane provides necessary space and time for the bone to heal and start regenerating itself.

Wharton's Jelly Tissue Allograft - Articular Disc of the TMJ


The five patients in this case series presented with chronic refractory TMD, specifically from severe degeneration of the structural tissues within the joint, and had failed standard-of-care practices for at least three months. After one application of Regenative’s Wharton’s Jelly allograft, the patient’s pain improved by an average of 75% after 90 days.

“Today, we see many physicians who are wary about treating TMJ and often revert to standard surgical treatments. Showing the outcomes that we have for patients will hopefully help to bolster more physicians to join us in using more conservative treatments. Our patients deserve more options,”


A recent publication of a novel case series

Studying the application of WJ, an umbilical cord connective tissue, to the structural tissue defect of the temporomandibular joint, set precedent for this non surgical allograft application.

Read the case study


Download the ICD-10 Code List to Identify Other Potential Use Sites.

Download Here

CryoText Product Information

For more information about our Cryotext product, visit the link below.

Pricing and PLACING AN order

For pricing or to place an order, login or setup an account to get immediate access to our MEDNGINE platform.


If you have any further questions, please contact us. We look forward to speaking with you!