Research Article
Abstract
Chronic Venous Insufficiency (CVI) is a long-term condition that can lead to significant personal and healthcare burdens. Impaired venous return may contribute to venous hypertension and valve dysfunction, which can progress to stasis dermatitis, infection, tissue breakdown, and venous ulceration. This case review documents the use of Dehydrated Amniotic Membrane Allograft (DAMA) as part of care for a chronic right lateral ankle ulcer associated with CVI.
The patient received weekly DAMA applications over six weeks. At the initial visit, the ulcer was wet, macerated, and accompanied by hemosiderosis and lipodermatosclerosis, correlating with a Venous Clinical Severity Score (VCSS) of 2. At the final evaluation, the wound was closed with a VCSS of 0. This case suggests DAMA may serve as a protective barrier and contribute to wound coverage when incorporated into a structured care protocol. Further prospective studies may help establish standardized application guidelines and inform treatment algorithms for venous ulcers.
Introduction
Chronic venous insufficiency affects more than 25 million adults in the United States and may impact up to 40% of the population. CVI is associated with approximately 80% of lower leg ulcer cases worldwide. Annual healthcare costs related to CVI are estimated at $3 billion and can range from inexpensive wound dressings to high-cost surgical interventions. When additional expenses such as transportation, therapy visits, and equipment needs are considered, the overall financial burden increases further. Chronic venous ulcers, especially among individuals with diabetes, require timely management, as they are a contributing factor in a large proportion of lower extremity amputations.