Regenerative Protocol for Ligamentous Defects in Sinus Tarsi
Sinus tarsi pain can result from strains or tears in the supporting ligaments of the subtalar region. Standard care often includes physical therapy, NSAIDs, bracing, and orthotics, yet many patients remain symptomatic.
This case series evaluates a multimodal regenerative protocol using Wharton’s jelly (WJ) tissue allografts, extracorporeal pulse-activated therapy (EPAT), class IV laser therapy, and biomechanical support in patients who previously failed conservative treatment.
Study Overview
- Design: IRB-approved case series (IRCM-2022-311)
- Participants: Five female patients (ages 50–72) with unilateral sinus tarsi pain unresponsive to prior standard care
- Intervention: EPAT, single 1Â cc WJ allograft application, class IV laser therapy, and orthotic/boot support
Clinical Significance
Patients reported an average VAS pain reduction of 85% over ~80 days, with improvements observed in all cases and no adverse reactions noted.
A Step Toward Evidence-Based Regenerative Care
WJ allografts contain collagen types I, III, and V as well as hyaluronic acid and proteoglycans, supporting their homologous role in ligamentous tissue repair. Findings align with existing literature on WJ in musculoskeletal applications and indicate the need for larger controlled studies.
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“Regenerative Protocol for Ligamentous Defects in Patients with Sinus Tarsitis: A Case Series.”